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Writer's pictureJason Galdo

Can You Drink on Antidepressants?



When you’re taking antidepressants, life can feel like it’s finally getting back on track. You’re working on your mental health, you’re finding a new balance, and maybe you’re even enjoying social events again. But here’s a big question that often comes up: Can you drink alcohol while on antidepressants?


The answer is not as straightforward as many might hope. While having a glass of wine or a beer may seem harmless, mixing alcohol and antidepressants can have significant effects on your mental and physical health. Let’s take a closer look at why doctors generally advise caution.


1. How Antidepressants Work in the Brain

Antidepressants like SSRIs (Selective Serotonin Reuptake Inhibitors), SNRIs (Serotonin and Norepinephrine Reuptake Inhibitors), and others work by balancing chemicals in the brain, particularly serotonin and norepinephrine. These chemicals help regulate mood, energy, and stress responses. By adjusting these chemicals, antidepressants can help alleviate symptoms of depression, anxiety, and other mood disorders.

Alcohol, on the other hand, is a depressant. It slows down the central nervous system, affecting things like balance, judgment, and overall mood. When you mix antidepressants with alcohol, the effects can sometimes counteract each other, making it harder for your medication to do its job effectively.


2. Increased Side Effects

Drinking on antidepressants can amplify side effects. Many antidepressants come with a range of side effects, including dizziness, drowsiness, and nausea. Alcohol can intensify these effects, leading to uncomfortable—and sometimes dangerous—situations. You may find that your tolerance for alcohol decreases, or that you experience stronger effects from smaller amounts.


3. Risk of Worsened Depression and Anxiety

While alcohol might make you feel temporarily relaxed, it can actually worsen depression and anxiety symptoms. Alcohol impacts brain chemicals, which can interfere with the benefits of antidepressants. If you’re taking antidepressants to manage depression or anxiety, alcohol may counteract the medication’s effect, making your symptoms harder to control.

Some people report feeling more anxious or depressed the day after drinking, sometimes known as “hangxiety.” For those on antidepressants, this feeling can be even more pronounced, leading to a cycle that’s hard to break.


4. Alcohol Can Reduce Medication Effectiveness

For antidepressants to work, they need consistency. Drinking alcohol can interfere with how well your body processes medication, possibly making it less effective. Alcohol can disrupt sleep and increase stress, both of which impact how well your medication works. Additionally, certain types of antidepressants like MAOIs (Monoamine Oxidase Inhibitors) can have severe reactions with alcohol, leading to dangerous spikes in blood pressure.


5. Potential for Risky Behavior

Alcohol impairs judgment and lowers inhibitions. Combining alcohol with antidepressants may increase the risk of impulsive actions, which could lead to risky decisions. This is especially important to consider if you’re dealing with depression, as alcohol can lower your mood and impair your decision-making abilities.


6. How to Approach Alcohol While on Antidepressants

If you want to have a drink, it’s essential to consult with your doctor. Some individuals may be able to enjoy small amounts of alcohol without significant issues, while for others, even one drink may cause problems. Each person’s body and brain respond differently, so there’s no universal rule.

Practical Tips if You Choose to Drink:

  • Limit yourself to one drink: If you do drink, limit yourself to one serving, which is generally considered to be one beer, one glass of wine, or one shot of liquor.

  • Take it slow: Drink slowly and listen to your body’s signals. You may feel the effects of alcohol more quickly when on antidepressants.

  • Drink plenty of water: Staying hydrated can help you stay aware of how alcohol affects you and reduce dehydration, which can worsen symptoms.

  • Monitor your mood: Check in with yourself after drinking. If you notice an increase in anxiety or depressive symptoms, it might be best to avoid alcohol in the future.


7. Alternative Ways to Relax

There are many ways to unwind and enjoy social settings without alcohol. Non-alcoholic beers, mocktails, and even sparkling water with a twist of lime can offer a similar experience. You could also explore other relaxation techniques like yoga, meditation, or even a new hobby to help manage stress without relying on alcohol.


While a drink here and there might seem harmless, mixing alcohol with antidepressants can bring on serious consequences. If you’re taking antidepressants, it’s best to discuss alcohol use with your doctor to understand how it may impact you specifically. Your mental health is important, and finding healthy ways to socialize and relax can make a big difference in supporting your wellness journey.


If you or a loved one are struggling with mental health issues, please give us a call today at 833-479-0797.


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