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What is the Best Drug for PTSD?

Writer's picture: Jason  GaldoJason Galdo

What is the Best Drug for PTSD?

Post-Traumatic Stress Disorder (PTSD) is a mental health condition triggered by experiencing or witnessing traumatic events. It can lead to flashbacks, nightmares, severe anxiety, and emotional numbness, all of which can disrupt daily life. While there are several treatments available for PTSD, including therapy and lifestyle changes, medication can play a critical role in managing its symptoms.

When considering the best drug for PTSD, it is important to note that medication alone is typically not sufficient. A comprehensive treatment plan, which may include therapy and other lifestyle adjustments, is essential for addressing the multifaceted nature of PTSD. Below, we explore some of the most common types of medications used to treat PTSD and how they work.


1. Selective Serotonin Reuptake Inhibitors (SSRIs)

SSRIs are considered the first-line treatment for PTSD and are often prescribed to help regulate mood and anxiety. These medications work by increasing the level of serotonin in the brain, which helps improve mood and reduce anxiety.

Common SSRIs used for PTSD:

  • Sertraline (Zoloft): Approved by the FDA for PTSD treatment, sertraline is one of the most frequently prescribed SSRIs. It can reduce symptoms of anxiety, depression, and intrusive thoughts.

  • Paroxetine (Paxil): Another commonly prescribed SSRI for PTSD, paroxetine has shown effectiveness in treating the anxiety and depression symptoms associated with the disorder.

SSRIs may take several weeks to begin working, and they can cause side effects such as nausea, insomnia, or sexual dysfunction. However, they are widely regarded as safe and effective for long-term treatment of PTSD.

2. Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)

SNRIs are similar to SSRIs but also affect norepinephrine, a neurotransmitter involved in mood regulation and the body’s stress response. These medications are often used when SSRIs do not provide enough relief.

Common SNRIs used for PTSD:

  • Venlafaxine (Effexor): Venlafaxine is FDA-approved for the treatment of anxiety and depression and can also help alleviate the symptoms of PTSD. It is effective in reducing the emotional numbness and irritability often seen in PTSD.

Like SSRIs, SNRIs can take several weeks to show noticeable effects and may cause side effects like dizziness, dry mouth, or increased blood pressure. Nevertheless, they can offer relief for those whose PTSD symptoms are not fully addressed by SSRIs.

3. Prazosin

Prazosin is an alpha-blocker typically used to treat high blood pressure, but it has also been found to be helpful for PTSD, particularly in managing nightmares and sleep disturbances, which are common in PTSD sufferers.

How it works: Prazosin works by blocking certain receptors in the brain that trigger the fight-or-flight response. This can be particularly helpful for people experiencing frequent nightmares, as it reduces the intensity of these distressing dreams. It is often prescribed for PTSD patients who struggle with sleep disruptions.

Prazosin has fewer side effects compared to other PTSD medications, although it can cause dizziness or lightheadedness, especially when standing up quickly. It’s generally well-tolerated when prescribed at the appropriate dosage.

4. Benzodiazepines

Benzodiazepines, such as Alprazolam (Xanax) and Lorazepam (Ativan), are sometimes used for short-term relief of severe anxiety and panic attacks associated with PTSD. These medications work quickly to calm the nervous system by enhancing the effects of a neurotransmitter called GABA.

Why they’re not ideal for long-term use: While benzodiazepines can provide fast relief, they are not recommended for long-term PTSD treatment. They can be addictive, and prolonged use can lead to tolerance and dependence. Because of these risks, benzodiazepines are typically prescribed only for short periods or during particularly difficult episodes of PTSD.

5. Other Medications

In some cases, individuals with PTSD may benefit from other medications that help with specific symptoms, such as antipsychotics, mood stabilizers, or anticonvulsants. These medications are typically considered when first-line treatments have not been effective.

Anticonvulsants (e.g., Lamotrigine): These may help manage irritability and mood swings associated with PTSD.

Antipsychotics (e.g., Olanzapine): Sometimes used to treat severe agitation or psychotic symptoms in PTSD patients.


There is no one-size-fits-all approach to treating PTSD, and the best medication will vary depending on the individual. SSRIs and SNRIs are commonly used as first-line treatments, while prazosin offers a unique benefit for sleep disturbances. Benzodiazepines may provide short-term relief but come with risks for dependency.

It is crucial for individuals with PTSD to work closely with a healthcare provider to determine the most appropriate medication, combined with therapy and other forms of support, to manage symptoms effectively and improve overall well-being.

If you or someone you know is dealing with PTSD, it’s important to seek professional help. Effective treatment is available, and recovery is possible with the right combination of therapy and medication.


If you or a loved one are struggling with mental health issues, please give us a call today at 833-479-0797.

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